Calf or back piece? It'd need to be pretty good sized to carry the thing off. Remember inks will spread a bit over time, newer inks not as badly as the really old stuff would but enough that you shouldn't want really fine lines and lots of ittsy bittsy detail. Find a really good artist, one who does a lot of intricate needlework, look at his art book (photos of previous stuff) show him what you have in mind and most importantly LISTEN to what he suggests. A lot can be 'suggested' by tone and shading.
I've got a Von Dutch inspired flying eyeball on my right bicep (7 in X 7 in) and in 11 years the outline ink has spread a little bit, the shading is still bright and tight, be aware, some folks don't 'take' yellow ink well and it fades quickly (not an issue with me) but I doubt mine would 'blob out' before I leave this plain of existance for the next one-got a few others, skulls, a skull smoking a ceegar, a first nations Raven and my first one, a flaming, stabbed broken heart (guess what inspired that).
Put the artwork somewhere that you can see it on a regular basis (like the door to the fridge)and see if you can live with it.
I think it would be very cool!